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For example, MDL29,951 stimulated calcium mobilization in GLUTag cells expressing hGPR17L-V96M with an EC 50 of 580 nM (pEC 50 = 6.24±0.07) and maximal stimulation that was 27±1.5% of that observed for hGPR17L-WT (Figure 4C)
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Another factor that might influence the regions targeted by the GLP-1R agonist is that blood–brain penetration is influenced by exposure to alcohol
